Table 9.1: Width versus critical charge of the NMOS transistors in a SRAM. Shepard hopes that this research, which was funded primarily by the National Science Foundation and the National Institutes of Health, will lead to exciting new applications for nanoscale electronic circuits. guard rings in a 0.18 m CMOS technology in order to improve the radiation. Our work, which has been a terrific collaboration between groups from Electrical Engineering, Chemistry, and Physics, is a great example of how nanoelectronics and biotechnology can be combined to produce new, exciting results." "There is a huge potential for modern nanoelectronics to play an important role in this field. "The area of single molecule research is an important one and pushes the envelope on our sensing systems," commented Ken Shepard, Professor of Electrical Engineering at Columbia Engineering. They also plan to study interactions at time scales several orders of magnitude greater than current techniques based on fluorescence. The Columbia team expects this new technique to be a powerful tool for looking at single molecule interactions and is looking at instrumentation applications that currently rely almost exclusively on fluorescence such as protein assays and DNA sequencing. While these are still emerging devices for electronics applications, they are exquisitely sensitive because the biomolecule can be directly tethered to the carbon nanotube wall creating enough sensitivity to detect a single DNA molecule. They have discovered that the answer is "yes." The transistors employed in this study are fashioned from carbon nanotubes, which are cylindrical tubes made entirely of carbon atoms. "So this raised the interesting question," said Sorgenfrei, the lead author on the study, "as to whether these very small transistors could be used to study individual molecules." The Columbia researchers, including Professor of Electrical Engineering Ken Shepard, Professor of Chemistry Colin Nuckolls, and graduate students Sebastian Sorgenfrei and Chien-Yang Chiu, realized that transistors, like those used in modern integrated circuits, have reached the same nanoscale dimensions as single molecules. But these techniques require that the target molecules being studied be labeled with fluorescent reporter molecules, and the bandwidths for detection are limited by the time required to collect the very small number of photons emitted by these reporters. These studies have yielded fundamental understanding of folding, assembly, dynamics, and function of proteins and other cellular machinery. At low V DD, this advantage diminishes slightly as the transistors operate in a regime which is less controlled by the barrier and more FET-like (Fig. 2 b and c depict smooth PCBM film on top of DNACTMA film and pentacene crystallites on the DNACTMA layers. Prior to this work, scientists have largely used fluorescence techniques to look at interactions at the level of single molecules. The surface morphology of low molecular weight DNACTMA (300 kDa), revealed a surface roughness <5 nm in such films as shown in Fig.
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